Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine (Pocket Notebook Series) by Sabatine Marc
Author:Sabatine, Marc [Sabatine, Marc]
Language: eng
Format: mobi, epub, pdf
ISBN: 9781469831411
Publisher: Lippincott Williams & Wilkins
Published: 2013-08-05T00:00:00+00:00
• Diagnosis: spherocytes on smear, Coombs’; ✓ cold agglutinin titer, splenomegaly
• Treatment: treat underlying disease
warm AIHA: corticosteroids ± splenectomy, IVIg, cytotoxic agents, rituximab
cold AIHA: avoid cold; steroids ineffective; rituximab (Blood 2004;103:2925)
Drug-induced hemolytic anemia
• Acquired, antibody-mediated, RBC destruction precipitated by a medication:
abx: cephalosporins, sulfa drugs, rifampin, ribavirin
CV: methyldopa, procainamide, quinidine, thiazides
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